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观察１７例无糖尿病既往史及家族史、且肾功能正常的肾病患儿于泼尼松治疗时糖代谢的改变。除检测尿糖、尿酮体外，以微量血糖测定仪侧空腹血糖，以放射免疫法测血胰岛素及胰高血糖素，并作了糖耐量试验。受试患儿于泼尼松治疗前后空腹血糖在正常范围，糖耐量仅１例于治疗３个月时轻度异常。但胰岛素基础分泌水平于泼尼松１．５～２．０ｍｇ·ｋｇ－１／ｄ服用１个月时测得水平显著增高，于隔日减量维持治疗时恢复至接近正常水平，提示用药后有胰岛素代偿分泌增高以维持血糖于正常水平。
17 patients with no history of diabetes and family history of renal disease were observed in children with prednisone treatment of glucose metabolism changes. In addition to the detection of urine sugar, urine ketone body, to trace blood glucose meter fasting blood glucose, radioimmunoassay to measure blood insulin and glucagon, and made glucose tolerance test. The subjects had a fasting blood glucose level within the normal range before and after prednisone treatment. Only 1 patient with impaired glucose tolerance was mildly abnormal at 3 months of treatment. However, the level of basal insulin secretion was significantly higher at 1 ~ 2 months after prednisone 1.5 ~ 2.0mg · kg-1 / d, and recovered to nearly normal level on the next day after maintenance therapy, suggesting that there was Increased insulin compensatory secretion to maintain normal blood glucose levels.