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目的：探讨内源性ＮＯ在应激状态下胃粘膜耐受性细胞保护中的作用及其可能的机制。方法：采用重复浸水束缚应激（ＷＲＳ）制作动物模型，动态监测胃粘膜血流量（ＧＭＢＦ）、血浆及粘膜内ＮＯ含量的变化。结果：重复应激伴有ＧＭＢＦ的上升以及血浆、粘膜内ＮＯ含量的增高，且ＧＭＢＦ与血浆、粘膜内ＮＯ含量之间呈显著正相关，但它们与粘膜损伤之间呈显著负相关。结论：内源性ＮＯ可能通过调节ＧＭＢＦ而介导了耐受性细胞保护作用
Objective: To investigate the role of endogenous nitric oxide in gastric mucosal-tolerant cytoprotection under stress and its possible mechanism. Methods: Animal models were established by repeated immersion restraint stress (WRS), and the changes of gastric mucosal blood flow (GMBF), plasma and mucosal NO contents were dynamically monitored. Results: The increase of GMBF and the increase of NO in plasma and mucosa were observed with repeated stress. There was a significant positive correlation between GMBF and plasma and mucosal NO content, but there was a significant negative correlation between GMBF and mucosal injury. CONCLUSION: Endogenous NO may mediate the protective effect of tolerogenic cells by regulating GMBF