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目的探讨自发性高血压脑出血患者血清神经元特异性烯醇化酶(NSE)、S100β蛋白水平与神经功能障碍程度的相关性。方法选择2014年6月-2015年10月诊断为自发性高血压脑出血患者120例,依据患者昏迷程度评分(格拉斯哥评分,GCS)分为轻症组(GCS≥8分)75例与重症组(GCS≤7分)45例。对于轻症组依据美国国立卫生研究院卒中量表(NIHSS)评分分为高分组38例与低分组37例。入院24h给予罗氏化学发光法检测血清NSE水平,应用ELISA检测S100β蛋白水平,对血清NSE、S100β蛋白与GCS、NIHSS水平相关性进行分析。结果重症组血清NSE、S100β蛋白水平明显高于对照组,差异均有统计学意义(P<0.05)。高分组与低分组血清NSE及S100β蛋白水平差异无统计学意义(P>0.05)。结论血清NSE、S100β蛋白水平与自发性高血压脑出血患者脑损伤严重程度关系密切,但其水平不能准确反映患者神经功能缺损程度。
Objective To investigate the correlation between serum neuron specific enolase (NSE), S100β protein level and neurological dysfunction in patients with spontaneous hypertensive cerebral hemorrhage. Methods One hundred and twenty patients diagnosed as spontaneous hypertensive intracerebral hemorrhage from June 2014 to October 2015 were divided into mild group (GCS≥8 points) and severe group (75 cases) according to the degree of coma of patients (Glasgow score, GCS) (GCS ≤ 7 points) in 45 cases. According to the National Institutes of Health Stroke Scale (NIHSS) score for the mild group, 38 were classified as high-grade group and 37 as low-grade group. Roche chemiluminescence was used to detect serum NSE level 24h after admission. The level of S100β protein was detected by ELISA, and the correlation between serum NSE, S100β protein and GCS and NIHSS was analyzed. Results Serum levels of NSE and S100β in severe group were significantly higher than those in control group (P <0.05). There was no significant difference in serum NSE and S100β protein levels between high-grade group and low-grade group (P> 0.05). Conclusion Serum levels of NSE and S100β are closely related to the severity of brain injury in patients with spontaneous hypertensive intracerebral hemorrhage, but their levels can not accurately reflect the degree of neurological deficits in patients.