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目的探讨p57kip2蛋白在贲门癌组织中的表达及其临床意义。方法采用免疫组织化学SP方法检测60例贲门癌和20例正常贲门组织(对照组)中p57kip2的表达情况,分析其与临床病理参数的关系。结果贲门癌组织中p57kip2蛋白表达率为43.4%(26/60),明显低于正常贲门黏膜中的表达率90%(18/20)(P<0.01);p57kip2的表达在不同临床分期及不同分化程度上差异有统计学意义(P<0.05),在有无淋巴结转移上差异无统计学意义(P>0.05)。结论 p57kip2参与贲门癌的发生、发展,可作为判定贲门癌恶性程度的重要生物学指标,可能在贲门癌的侵袭和转移过程中起重要作用。
Objective To investigate the expression of p57kip2 protein in cardia carcinoma and its clinical significance. Methods The expression of p57kip2 in 60 cases of cardia carcinoma and 20 cases of normal cardia tissue (control group) was detected by immunohistochemical SP method. The relationship between p57kip2 and clinicopathological parameters was analyzed. Results The expression of p57kip2 protein in gastric cardia was 43.4% (26/60), which was significantly lower than that in normal cardia (90%, 18/20) (P <0.01). The expression of p57kip2 in different clinical stages and different Differences in the degree of differentiation was statistically significant (P <0.05), with or without lymph node metastasis was no significant difference (P> 0.05). Conclusion The occurrence and development of p57kip2 in cardia cancer may be used as an important biological index to determine the degree of malignancy of cardia cancer, which may play an important role in the invasion and metastasis of cardia cancer.