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近来研究发现，ＩｇＧ亚类（ＩｇＧ１、ＩｇＧ２ 、ＩｇＧ３ 、ＩｇＧ４）水平的异常是导致反复呼吸道感染、中耳炎及其它免疫缺陷病的重要原因，由此开展免疫球蛋白Ｇ亚类的检测对临床诊断具有重要的实用价值。本文采用了酶联免疫吸附试验方法略加改进检测ＩｇＧ 亚类，共测标本８３ 例，包括肺炎、哮喘、肾炎和肾病。１９ 例哮喘患儿中１７ 例ＩｇＧ亚类水平异常，其中ＩｇＧ１ 和ＩｇＧ２ 降低较为显著，部分患儿伴有ＩｇＧ３ 和ＩｇＧ４ 的异常，与报道一致。肾炎患儿以ＩｇＧ１ 降低为主，部分患儿ＩｇＧ２ 降低，肾病患儿以ＩｇＧ１ 和ＩｇＧ２ 降低为主，均伴有ＩｇＧ３ 或ＩｇＧ４ 的异常。当一种ＩｇＧ 亚类缺陷时，常伴有其它ＩｇＧ亚类代偿性增高，以致血清总ＩｇＧ水平正常或略为升高。本文报道的哮喘和肾炎患儿中分别都有其总量正常，而其中一种或几种亚类增高，目前肾炎和肾病的ＩｇＧ亚类测定尚未见报道，其病理生理意义尚不明确。在本实验中，对检测方法作了改进。
Recent studies have found that the abnormalities of IgG subclasses (IgG1, IgG2, IgG3, IgG4) are important causes of recurrent respiratory tract infections, otitis media and other immunodeficiency diseases. Therefore, the detection of immunoglobulin G subclasses has clinical significance in clinical diagnosis Important practical value. In this study, enzyme-linked immunosorbent assay was used to improve the detection of IgG subtypes in 83 cases, including pneumonia, asthma, nephritis and nephropathy. In 19 cases of asthma, 17 cases of IgG subclass levels abnormalities, including IgG1 and IgG2 decreased significantly, some patients with abnormal IgG3 and IgG4, consistent with the report. Neonatitis in children with IgG1 reduced, some children with IgG2 decreased, nephropathy in children with IgG1 and IgG2 decreased mainly associated with IgG3 or IgG4 abnormalities. When an IgG subclass deficiency, often accompanied by compensatory increase of other IgG subclasses, resulting in normal or slightly elevated serum total IgG levels. In this paper, children with asthma and nephritis respectively have their total amount of normal, but one or more of them are increased. At present, the IgG subclass of nephritis and nephropathy has not been reported, and its pathophysiological significance is not yet clear. In this experiment, the detection method has been improved.