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药物与激素作用于效应器官的两个主要特征是它们的有效浓度往往很低以及产生特定效应有严格的结构特异性。药物或激素分子中微小的结构改变可导致失活。药物与激素的这二个基本特点,即高度的亲和性与严格的特异性,使内分泌学家和药理学家早在15年前就认为体内必定存在一些称为“受体”的细胞组分,它们和药物或激素特异性地牢固结合,由此产生药物作用。肾上腺素放射性配体的发展30年前,Ahlquist首先提出二种主要类型
The two main features of drugs and hormones acting on effector organs are their often low effective concentrations and the strict structural specificity to produce specific effects. Slight structural changes in drug or hormone molecules can lead to inactivation. The two basic characteristics of drugs and hormones, namely, high affinity and strict specificity, make endocrinologists and pharmacologists think that there must be some cell groups called “receptors” in vivo as early as 15 years ago They are specifically and strongly bound to drugs or hormones, resulting in drug effects. The adrenaline radioligand development 30 years ago, Ahlquist first proposed two main types