前列腺特异性抗原在前列腺增生和前列腺肿瘤中的鉴别诊断价值

• 作 者: 邓芝云 于兰 权淼 高福兴 董菊子 张银霞
• 机 构: 兰州军区兰州总医院,兰州医学高等专科学校
• 出 处: 上海免疫学杂志
• 发表日期: 1999年03期
• 关键词: 前列腺肿瘤 前列腺增生 鉴别诊断 临床分期 诊断效率 特异性 前列腺体积 前列腺特异抗原 阳性预测值 前列腺穿刺

为评价前列腺特异性抗原（ＰＳＡ）及其密度（ＰＳＡＤ）对前列腺增生（ＢＰＨ）和肿瘤的鉴别诊断价值，采用放射免疫法对３０例前列腺癌（Ｐｃａ）和８０例ＰＢＨ患者进行了检测。结果发现：Ｐｃａ患者的平均血清ＰＳＡ含量显著高于ＢＰＨ患者，且界线以１０μｇ／Ｌ时的敏感性、特异性、准确性及诊断效率为高，分别为５０％、９１３％、８０％和４５７％；Ｐｃａ患者的ＰＳＡＤ值也明显高于ＢＰＨ者，当界线值≥０２时，其诊断的敏感性为９６７％，特异性为８５％，准确性为８８２％，诊断效率为８８２％，阴、阳性预测值也较理想。ＰＳＡ随病情进展升高，而ＰＳＡＤ则随病情进展下降，表明ＰＳＡ与临床分期成正相关而ＰＳＡＤ则成负相关，ＰＳＡＤ较ＰＳＡ对Ｐｃａ及ＰＢＨ更具有鉴别诊断意义。

To assess the differential diagnostic value of prostate-specific antigen (PSA) and its density (PSAD) on benign prostatic hyperplasia (BPH) and tumors, 30 cases of prostate cancer (Pca) and 80 cases of PBH were examined by radioimmunoassay. The results showed that the average serum PSA level in patients with Pca was significantly higher than that in patients with BPH, and the sensitivity, specificity, accuracy and diagnostic efficiency of the patients with BPH were 50%, 913%, 80% And 457%, respectively. The PSAD value of Pca patients was also significantly higher than that of BPH patients. When the borderline value was ≥02, the diagnostic sensitivity and specificity were 967%, 85% and 882, respectively %, The diagnostic efficiency of 88  2%, negative, positive predictive value is also more ideal. PSA progresses with the progression of the disease, and PSAD with the progress of the decline, indicating that PSA is positively correlated with clinical stage and PSAD is negatively correlated, PSAD compared with PSA Pca and PBH more differential diagnostic significance.