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目的探讨IL-10在系统性红斑狼疮(SLE)发病中的作用及意义。方法选择2011年1月~2013年6月符合入组标准的103例SLE患者及32例健康人进行研究，其中SLE患者初发期组63例，缓解期组40例，采用酶联免疫吸附试验(ELISA)检测外周血IL-10水平,同时根据SLEDAI评分对初发期组SLE患者进行分析。结果与健康对照组比较，SLE初发期组及缓解期组IL-10水平明显升高，同时初发期组IL-10水平亦明显高于缓解期组，三组间对比差异具有统计学意义（<0.05）；按SLEDAI评分将SLE初发期组患者分为轻度活动组21例、中度活动组30例、重度活动组12例，比较三组间IL-10水平差异具有统计学意义（<0.05），并且IL-10水平与SLEDAI评分呈显著正相关。结论 IL-10参与了SLE的免疫损伤过程，且与病情活动及严重程度有关。“,”Objective To investigate the serum levels of IL-10 and their significance in patients with Systemic Lupus Erythematosus (SLE).Methods A total of 135 cases were available for the study including 63 cases of primary group, 40 cases of remission group and 32 cases of healthy control group.ELISA method was used to determine the concentrations of IL-10 in serum.Results The levels of IL-10 in serum of primary group were significantly higher than that of remission group and healthy control group. The levels of IL-10 in serum of remission group were significantly higher than that of healthy control group( <0.05). 63 cases of primary group were divided into three groups by SLEDAI:21 cases in mild activities group, 30 cases in moderate activities group,12 cases in severe activities group, the levels of IL-10 among the three groups were significant dif erence ( <0.05). The levels of IL-10 in primary group had active cor elation with SLEDAI. Conclusion IL-10 is involved in the immune damage process and associated with activity and severity in patients with SLE.