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恶性肿瘤患者常常死于浸润和转移,作为癌组织重要的生物学特性一浸润、转移一直是人们研究的热点,而基质金属蛋白酶(MMPs)在肿瘤的浸润和转移中起重要作用,其活性可被内源性的组织金属蛋白酶抑剂(TIMPs)抑制,目前已有几种基质金属蛋白酶抑制剂药物(如巴马司他)进入了Ⅲ期临床试验阶段,但其广谱抑制作用对机体所产生的副作用显著阻碍了其进一步的发展,效果均不太理想。而RECK(reversion-inducing cysteine-rich protein with
Patients with malignant tumors often die of infiltration and metastasis. As an important biological characteristic of cancer tissues, invasion and metastasis have always been the hot topics of research. Matrix metalloproteinases (MMPs) play an important role in tumor invasion and metastasis. Inhibition of endogenous tissue inhibitors of metalloproteinases (TIMPs), there are already several matrix metalloproteinase inhibitor drugs (such as bumastat) into the phase Ⅲ clinical trial phase, but its broad-spectrum inhibitory effect on the body The side effects produced significantly impede its further development, the effect is not ideal. RECK (reversion-inducing cysteine-rich protein with