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用特异性放射免疫法对19例健康人、19例浅表性胃炎、16例胃癌患者胃液和血浆表皮生长因子(EGF)、胃泌素(GAS)浓度进行了测定,结果表明:①胃癌胃液EGF和GAS浓度均显著高于健康对照和浅表性胃炎组,且二者呈显著正相关性(γ=0.614,P<0.01);②胃癌血浆EGF却低于其它2组(P<0.05);③血浆GAS 3组无显著差别。提示:胃液EGF和GAS与胃癌有一定关系,二者可能协同促进肿瘤生长,胃癌组织可能有自分泌EGF和GAS的作用。
Gastric fluid and plasma epidermal growth factor (EGF) and gastrin (GAS) concentrations in 19 healthy individuals, 19 patients with superficial gastritis, and 16 patients with gastric cancer were measured by specific radioimmunoassay. The results showed that: 1 gastric cancer gastric juice The concentrations of EGF and GAS were significantly higher than those of healthy controls and superficial gastritis group, and there was a significant positive correlation between them (γ=0.614, P<0.01).2 The plasma EGF of gastric cancer was lower than that of other two groups (P<0.05). ;3 There was no significant difference in plasma GAS 3 group. Tip: Gastric juice EGF and GAS have a certain relationship with gastric cancer, the two may synergistically promote tumor growth, gastric cancer tissue may have autocrine EGF and GAS role.