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目的观察埃索美拉唑联合莫沙必利治疗反流性食管炎的疗效。方法将90例患者随机分为治疗组(45例)和对照组(45例)。治疗组:埃索美拉唑40mg,1次/d;莫沙必利5mg,3次/d口服。对照组:埃索美拉唑40mg,1次/d口服。治疗前及治疗后2、4、6周计算患者症状积分。治疗后6周复查胃镜,观察胃镜下愈合率。结果治疗组临床有效率为100%,内镜下有效率为97.8%;对照组分别为86.7%和84.4%,两组比较差异有显著性(P<0.05)。结论埃索美拉唑联合莫沙必利治疗反流性食管炎比单用埃索美拉唑具有更好的疗效。
Objective To observe the efficacy of esomeprazole combined with mosapride in the treatment of reflux esophagitis. Methods Ninety patients were randomly divided into treatment group (45 cases) and control group (45 cases). Treatment group: esomeprazole 40mg, 1 / d; mosapride 5mg, 3 times / d orally. Control group: esomeprazole 40mg, 1 time / d orally. Before treatment and 2, 4, 6 weeks after treatment, patients’ symptom scores were calculated. Gastroscopy was performed 6 weeks after treatment to observe the healing rate under gastroscope. Results The clinical effective rate was 100% in the treatment group and 97.8% in the endoscopic group. The control group was 86.7% and 84.4% respectively, with significant difference between the two groups (P <0.05). Conclusion Esomeprazole combined with mosapride in the treatment of reflux esophagitis is more effective than esomeprazole alone.