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目的探讨早期目标导向治疗(early goal-directed therapy,EGDT)在治疗感染性休克(septic shock)时对感染性休克患者肾功能的影响。方法100例感染性休克患者分为治疗组和对照组,对照组进行常规治疗,治疗组在早期目标导向治疗上达标。观察患者的临床症状改善情况,常规检测患者血清肌酐(Cr)、尿素氮(BUN)水平,观察早期目标导向治疗对感染性休克患者肾功能的影响。结果治疗组中发病后<24h及24～72h患者出现肾损伤发生率分别为22%和33%,对照组分别为44%和50%,两组比较差异有统计学意义(p<0.05)。结论早期目标导向治疗在治疗感染性休克时可以显著减少急性肾损伤的发病率,对感染性休克患者肾功能有明显保护作用。
Objective To investigate the effect of early goal-directed therapy (EGDT) on renal function in patients with septic shock during septic shock. Methods One hundred patients with septic shock were divided into treatment group and control group. The control group was treated routinely, and the treatment group achieved the goal of early target-oriented therapy. The clinical symptoms of the patients were observed. The levels of serum creatinine (Cr) and blood urea nitrogen (BUN) were measured routinely to observe the effect of early targeted therapy on renal function in septic shock patients. Results The incidence of renal injury in the treated group was 22% and 33%, respectively, at 24h and 24 ~ 72h after operation, compared with 44% and 50% in the control group, respectively. There was significant difference between the two groups (p <0.05). Conclusion Early goal-directed therapy can significantly reduce the incidence of acute kidney injury in the treatment of septic shock and has a significant protective effect on renal function in septic shock patients.