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本文初步研究了肿瘤细胞NK敏感性与转移之间的关系。实验发现,用放线菌素D(2.5μg/ml)预处理B16-黑色素可显著增高NK敏感性;且在体内易被清除;在肺中形成血源转移瘤灶数也显著减少。结果提示,肿瘤细胞NK敏感性的改变可能影响其血源转移能力。
This article initially studied the relationship between tumor cell NK sensitivity and metastasis. It was found that pretreatment of B16-melanin with actinomycin D (2.5 μg/ml) significantly increased NK sensitivity and was easily eliminated in vivo; the number of blood-borne metastases formed in the lungs was also significantly reduced. The results suggest that changes in the NK sensitivity of tumor cells may affect their ability to metastasize to blood.