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作者采用随机双盲法比较多沙唑嗪(doxazosin)和依那普利(enalapril)治疗轻中度高血压病的效果和安全性。 54例高血压病患者(卧位和立位舒张压12.66～15.20kPa)随机分为多沙唑嗪组(27例)和依那普利组(27例),两组的平均年龄为51.2和51.7岁。研究采用双盲法。多沙唑嗪组平均日剂量为4.4mg,依那普利组为19.3mg;两组的平均治疗时间分别为81.5和82天。结果两组血压均较治疗前显著降低,但两组之间血压变化无差异(均P<0.05)。
The authors compared the efficacy and safety of doxazosin and enalapril in the treatment of mild-to-moderate hypertension by a double-blind randomized trial. 54 patients with hypertension (lying and standing diastolic pressure 12.66 ~ 15.20kPa) were randomly divided into doxazosin group (27 cases) and enalapril group (27 cases), the average age of both groups was 51.2 and 51.7 years old. Study using double-blind method. The average daily dose of doxazosin group was 4.4 mg and that of enalapril group was 19.3 mg. The mean treatment time was 81.5 and 82 days for both groups. Results The blood pressure in both groups was significantly lower than that before treatment, but there was no significant difference in blood pressure between the two groups (all P <0.05).