静脉输注的染料木黄酮和镁通过内皮保护作用及抑制大电导钙激活钾通道增强对自发性高血压大鼠的降压作用

• 作 者: Sun L Zhao T Ju T Wang X Li X Wang L Zhang L Yu G 练桂丽 叶鹏
• 出 处: 中华高血压杂志
• 发表日期: 2016年02期
• 关键词: 染料木黄酮 正常血压 spontaneously hypertensive 降压作用 高血压 静脉输注 钾通道 联用 大鼠

在12周龄的雄性自发性高血压大鼠(spontaneously hypertensive rat,SHR)28只中,研究者评估染料木黄酮(GST)和镁(Mg)联用对高血压发展的影响。实验分为4组:SHR[0.9%NaCl和二甲基亚砜(DMSO)]、SHR+GST[(0.9%NaCl和GST 5 mg/(kg·d)]、SHR+Mg[Mg2+0.75 mmol/(kg·d)和DMSO]、SHR+GST+Mg[Mg2+0.75mmol/(kg·d)和GST 5 mg/(kg·d)]。还纳入1组正常血压的

The researchers evaluated the effects of genistein (GST) and magnesium (Mg) on ​​the development of hypertension in 28, 12-week-old male spontaneously hypertensive rats (SHRs). The experiment was divided into 4 groups: SHR [0.9% NaCl and DMSO], SHR + GST ​​[(0.9% NaCl and GST 5 mg / (kg · d) (kg · d) and DMSO], SHR + GST ​​+ Mg [Mg2 + 0.75 mmol / (kg · d) and GST 5 mg / (kg · d)