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探讨血清和支气管肺泡灌洗液（ＢＡＬＦ）中肿瘤标志物联合检测对肺癌诊断的价值。方法：采用放射免疫分析方法对癌胚抗原（ＣＥＡ）、铁蛋白（ＦＴ）和β_２－微球蛋白（β_２－ＭＧ）进行分析。结果：肺癌患者血清及ＢＡＬＦ中ＣＥＡ、ＦＴ浓度均明显高于肺良性病变组，两组比较有显著性差异（Ｐ＜０．０１或Ｐ＜０．０５）。ＢＡＬＦ中ＣＥＡ、ＦＴ的浓度高于血清浓度，且腺癌ＣＥＡ和ＦＴ浓度高于鳞癌和小细胞未分化癌。β_２－ＭＧ的血清和ＢＡＬＦ浓度两组比较无显著性差异（Ｐ＞０．０５）。结论：肿瘤标志物联合测定可提高肺癌诊断的敏感性、特异性和准确性，对肺癌的早期诊断有辅助价值。
To explore the value of combined detection of serum markers and tumor markers in bronchoalveolar lavage fluid (BALF) in the diagnosis of lung cancer. Methods: Carcinoembryonic antigen (CEA), ferritin (FT) and β 2 -microglobulin (β 2 -MG) were analyzed by radioimmunoassay. Results: The concentrations of CEA and FT in serum and BALF in patients with lung cancer were significantly higher than those in benign lung lesions. There was a significant difference between the two groups (P<0.01 or P<0.05). The concentrations of CEA and FT in BALF were higher than those in serum, and the CEA and FT concentrations in adenocarcinoma were higher than those in squamous cell carcinoma and small cell undifferentiated carcinoma. There was no significant difference in serum and BALF concentrations of β 2 -MG between the two groups (P>0.05). Conclusion: The combined determination of tumor markers can improve the sensitivity, specificity and accuracy of lung cancer diagnosis, and have an auxiliary value for the early diagnosis of lung cancer.