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目的研究分析四君子汤加减联合化疗对大肠癌术后患者癌胚抗原(CEA)和糖链抗原199(CA199)变化的影响。方法 68例行大肠癌术患者,随机分为观察组与对照组,各34例。观察组术后采用四君子汤辨证加减联合化疗,对照组仅采用化疗。观察并比较两组患者CEA、CA199变化。结果两组患者经化疗后,CEA以及CA199均有所下降,但观察组CEA、CA199较对照组降低更明显,差异均具有统计学意义(P<0.05)。结论大肠癌术后化疗时联合四君子汤,能明显降低CEA、CA199,值得推广应用。
Objective To study the effect of Si Junzi Decoction combined with chemotherapy on the changes of carcinoembryonic antigen (CEA) and carbohydrate antigen 199 (CA199) in postoperative patients with colorectal cancer. Methods 68 cases of colorectal cancer patients were randomly divided into observation group and control group, 34 cases each. The observation group was treated with Sijunzi decoction combined with chemotherapy and the control group only with chemotherapy. The changes of CEA and CA199 in both groups were observed and compared. Results After chemotherapy, CEA and CA199 decreased in both groups. However, CEA and CA199 in the observation group were significantly lower than those in the control group, with statistical significance (P <0.05). Conclusion Combined chemotherapy with Sijunzi Decoction for postoperative chemotherapy of colorectal cancer can significantly reduce CEA and CA199, which is worth popularizing and applying.