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髓过氧化物酶是一种白细胞酶,在动脉粥样硬化患者的腐蚀或破裂斑块中活性明显升高,参与动脉粥样硬化的发生发展过程。研究表明,髓过氧化物酶与炎症和心血管疾病间存有关联。本文就髓过氧化物酶的结构、生物学作用、基因多态性及其与动脉粥样硬化关系的研究进展作一综述。
Myeloperoxidase is a leukocyte enzyme that is significantly elevated in the atherosclerotic plaques of patients with erosion or rupture and is involved in the development of atherosclerosis. Research shows that myeloperoxidase is associated with inflammation and cardiovascular disease. This review summarizes the research progress on the structure, biological function, gene polymorphism of myeloperoxidase and its relationship with atherosclerosis.