Carboxypeptidase E (NF-α1):a new trophic factor in neuroprotection

• 作 者: Yong Cheng Niamh X.Cawley Y.Peng Loh
• 机 构: Section on Cellular Neurobiology,Program on Developmental Neuroscience,Eunice Kennedy Shriver Nation
• 出 处: Neuroscience Bulletin
• 发表日期: 2014年04期
• 关键词: trophic NF-α1 sorting hippocampal regulate cortex neuronal concomitant neurotrop

Carboxypeptidase E(CPE) is a prohormone-processing enzyme and sorting receptor that functions intracellularly.However, recent studies have demonstrated that CPE acts as a trophic factor extracellularly to up-regulate the expression of a pro-survival gene.This mini-review summarizes the roles of CPE in neuroprotection and the implications for neurodegenerative diseases.

Carboxypeptidase E (CPE) is a prohormone-processing enzyme and sorting receptor that functions intracellularly. Recent studies have demonstrated that CPE acts as a trophic factor extracellularly to up-regulate the expression of a pro-survival gene. This mini-review summarizes the roles of CPE in neuroprotection and the implications for neurodegenerative diseases.