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二甲亚砜（ＤＭＳＯ）和维生素Ｅ（ＶｉｔＥ）都是自由基清除剂，可抑制或阻断由自由基引发的脂质过氧化反应，减轻组织损伤和细胞的破坏。本研究应用荧光分光光度法，通过测定小鼠血清中脂质过氧化代谢产物丙二醛（ＭＤＡ）的含量来研究不同浓度的ＤＭＳＯ和维生素Ｅ对γ射线照射后小鼠的保护作用，以及两者联合应用的效果。结果表明：ＤＭＳＯ的保护作用优于ＶｉｔＥ，最大脂质过氧化抑制率（４．０Ｇｙ）分别为５５．１％和５３．６％，两者的最佳用量分别为１０ｍｇ／ｇ体重和０．２５ｍｇ／ｇ体重，联合用药的作用效果（最大脂质过氧化抑制率为６０．１％）大于单独使用时的效果。
Both dimethylsulfoxide (DMSO) and vitamin E (VitE) are free radical scavengers that inhibit or block free radical induced lipid peroxidation and reduce tissue damage and cell destruction. In this study, fluorescence spectrophotometry was used to study the protective effect of different concentrations of DMSO and vitamin E on mice after γ-ray irradiation by measuring the content of malondialdehyde (MDA), a lipid peroxidation metabolite in mouse serum, The effect of joint application. The results showed that the protective effect of DMSO was better than that of VitE, and the maximum inhibition rates of lipid peroxidation (4.0Gy) were 55.1% and 53.6%, respectively. The optimum dosages were 10 mg / g body weight and 0 respectively. 25mg / g body weight, the combined effect of the drug (maximum lipid peroxidation inhibition rate of 60.1%) than when used alone.