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上海交通大学医学院附属和平妇幼保健院黄荷凤院长领衔的课题组发现,女性妊娠前高雄激素症可能增加子代糖代谢异常的风险,而表观遗传改变的传代效应可能是其分子机制之一。这项研究成果近日在线发表于Cell出版社和The Lancet杂志支持的EBio Medicine杂志。高雄激素症是育龄期妇女常见的生殖内分泌疾病之一,其发生率在不孕人群中高达15%。既往的研究表明,卵泡内过多的雄激素干扰卵子发育潜能,并进一步影响受精和胚胎发育。近年来,通过辅助生殖技术的应用,高雄激素症
The research group led by Dean Huang Ho-feng, a professor at Shanghai Jiao Tong University School of Medicine at Peace Maternal and Child Health Hospital, found that pre-pregnancy hyperandrogenism may increase the risk of abnormal glucose metabolism in offspring, while the epigenetic effects may be one of the molecular mechanisms . The research was recently published online in EBIO Medicine magazine, powered by Cell Press and The Lancet magazine. Hodgkin’s disease is one of the common reproductive and endocrine diseases in women of childbearing age, with a prevalence of up to 15% in infertile women. Previous studies have shown that too much androgen in the follicle interferes with egg developmental potential and further affects fertilization and embryonic development. In recent years, through the application of assisted reproductive technology, hyperandrogenism