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目的 研究乳腺癌术前化疗对罗库溴铵肌松效应的影响.方法 全麻下肌松监测乳腺癌手术患者43例,分为术前化疗组(A组,25例)和未进行化疗组(B组,18例).两组术前均未用对肌松有影响的药物.用加速度仪监测拇内收肌收缩反应,观察罗库溴铵0.6 mg/kg静注后肌松时效的差异.结果 A、B两组起效时间分别为(93±18)S和(96±19)s,差异无统计学意义;A组临床时效长于B组[(49±16)min vs.(37±13)min],A组恢复指数也长于B组[(14.2±3.0)min vs.(10.9±2.5)min](P<0.05).结论 乳腺癌术前化疗对罗库溴铵的临床作用时效和恢复延长.“,”Objective To investigate the effect of chemotherapy on neuromuscular blocking of rocuronium in patients undergoing brest cancer. Methods Forty-three femail patients undergoing selective brest cancer operation under general anesthesia were divided into 25 patients who had received chemotherapy before surgery(group A)and 18 cases who had not(group B).The neuromuscular function was monitored by TOF stimulation using accelerograph.The onset time,clinical duration of action and recovery index were recorded after rocuronium 0.6 mg/kg was administered iv.Results The onset times of group A and group B were (93±18) s in and (96±19) s, respectively. The clinical duration of action in group A was (49±16) min. which was longer than(37±19)min in group B(P<0.05).So did the recovery inde)[[(14.2±3.0)min vs.(10.9±2.5)min(P<0.05).Conclusion Chemotherapy before surgery could make the clinical duration of action and recovery of rocuromum in patients with brest cancer.