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树突状细胞(DCs)是固有免疫和适应性免疫之间的桥梁,负责感受和巡视外界环境,发动宿主免疫反应并指导适当的抗病原体适应性免疫反应的进行。时代的推移使得人类疾病谱随之而变,肿瘤、免疫缺陷病等日益增多,医学发展的日新月异带来了更多重症和难治性疾病的治疗新手段,如器官移植、化疗、免疫抑制剂的应用增加,但同时也引起一系列不良事件的发生,如导致威胁人类生命的真菌物种的产生。其中3种机会致病真菌构成对免疫缺陷宿主最大程度的威胁:烟曲霉、白念和新生隐球菌。而在这3种机会致病真菌当中,白念珠菌又是最为常见的。白念珠菌入侵人体的第1道防线即是DCs,后者可将其吞噬并提呈抗原至适应性免疫细胞,从而引发一系列下游反应。在此,我们将对DCs在这一过程中发挥作用的机制及带来的结果作一文献综述。
Dendritic cells (DCs) serve as a bridge between innate and adaptive immunity and are responsible for sensing and inspecting the external environment, initiating host immune responses and directing appropriate adaptive pathogen-resistant immune responses. The passage of time makes the spectrum of human diseases change, tumor and immunodeficiency diseases are increasing, and the rapid development of medicine brings more new treatments for severe and refractory diseases such as organ transplantation, chemotherapy, immunosuppressive agents Increased but also caused a series of adverse events, such as the production of fungal species that threaten human life. Three of these opportunistic pathogenic fungi pose the greatest threat to immunodeficiency hosts: A. fumigatus, C. albicans and C. neoformans. In these three opportunistic pathogenic fungi, Candida albicans is the most common. Candida albicans invade the body’s first line of defense is DCs, which can swallow and antigen presentation to adaptive immune cells, which led to a series of downstream reactions. Here, we will make a literature review of the mechanisms by which DCs play a role in this process and the results.