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目的 :探讨头颈鳞癌血管生成与其颈淋巴结转移的关系以及血管内皮生长因子(VEGF)在头颈鳞癌血管生成中的作用。方法 :应用免疫组化SABC法检测 5 8例头颈鳞癌组织中微血管密度 (IMVD)及VEGF的表达。结果 :5 8例头颈鳞癌组织中IMVD为 2 3.93± 8.77,肿瘤分化程度 ,高与中、高与低间 ,IMVD差异有显著性意义 (均P <0 .0 5 ) ;中与低间 ,差异无显著性意义 (P >0 .0 5 )。颈淋巴结转移组IMVD(2 7.92± 9.11)明显高于非转移组 (2 0 .6 9± 7.0 8) ,其差异有显著性意义 (P <0 .0 1)。癌组织中VEGF表达与瘤内IMVD呈正相关 (rs=0 .4 87,P <0 .0 1)。结论 :瘤内IMVD可作为预测头颈鳞癌颈淋巴结转移的一个重要指标 ;VEGF可促进头颈鳞癌血管生成。
Objective: To investigate the relationship between angiogenesis of cervical squamous cell carcinoma and cervical lymph node metastasis and the role of vascular endothelial growth factor (VEGF) in angiogenesis of head and neck squamous cell carcinoma. Methods: Immunohistochemical SABC method was used to detect the microvessel density (IMVD) and the expression of VEGF in 58 cases of head and neck squamous cell carcinoma. Results: The IMVD in 58 cases of head and neck squamous cell carcinoma was 2 3.93 ± 8.77. There was significant difference in IMVD between the high, medium, high and low tumors (all P <0.05) , No significant difference (P> 0.05). IMVD (2 7.92 ± 9.11) in cervical lymph node metastasis group was significantly higher than that in non-metastasis group (20.96 ± 7.08), the difference was significant (P <0.01). The expression of VEGF in cancer tissue was positively correlated with the IMVD (rs = 0.487, P <0.01). Conclusion: Intratumoral IMVD can be used as a predictor of cervical lymph node metastasis of head and neck squamous cell carcinoma; VEGF can promote angiogenesis of head and neck squamous cell carcinoma.