柴枳朴槟汤原方及拆方对大鼠血浆胃动素水平的影响

• 作 者: 陈文莉 郭良集 张亚妮 凌昌全
• 机 构: 上海市宝山区中医医院内科,上海市宝山区中医医院内科,第二军医大学附属长海医院中医科,第二军医大学附属长海医院中医科 上海201900,上海201900,上海200433,上海200433
• 出 处: 中国中西医结合消化杂志
• 发表日期: 2007年03期
• 关键词: 柴枳朴槟汤 胃动素 实验研究

[目的]观察柴枳朴槟汤原方及拆方对大鼠血浆胃动素(MOT)水平的影响。[方法]取大鼠随机分成对照组、理气A组、理气B组、活血A组、活血B组、理气活血A组、理气活血B组、甘草组8组,灌胃14 d后进行血浆MOT水平的检测。[结果]理气活血B组(柴枳朴槟汤原方)、理气A组、活血A组MOT水平明显增高,与对照组比较差异均有统计学意义(P<0.05,<0.01);甘草组MOT水平降低,与对照组比较差异有统计学意义(P<0.05);理气B组、活血B组、理气活血A组与对照组比较差异均无统计学意义。[结论]柴枳朴槟汤原方及拆方对大鼠血浆MOT水平的影响各不同,推测可能方中理气药、活血药能升高大鼠血浆MOT水平,而甘草抑制其水平。3组药物配伍后能协同作用。

[Objective] To observe the effect of Chai Qin Pu-Qin Tang Yuan Fang and Decoction on plasma motilin (MOT) level in rats. [Methods] Rats were randomly divided into control group, qi A group, qi B group, Huoxue A group, Huoxue B group, Liqi Huoxue A group, Liqi Huoxue B group, and Licorice group 8. The rats were treated with plasma MOT after 14 days. Level detection. [Results] The MOT levels in the Qiqihuoxue B group (Chaiqin Pu-Qin Tangyuan prescription), qi A group, and Huoxue A group were significantly increased, and there were significant differences compared with the control group (P<0.05, <0.01); MOC levels in the licorice group The difference between the control group and the control group was statistically significant (P<0.05). There was no significant difference between the qi-B group, the Huoxue B group, and the Liqi Huoxue A group compared with the control group. [Conclusion] The effects of Chai Qin Pu-Qin Tang Yuan Fang and Decoction on the plasma MOT levels in rats are different. It is speculated that the prescriptions of Qi-Liqi and Huoxue Decoction can increase the plasma MOT level in rats, while Glycyrrhiza uralensis inhibits the level. After the combination of three groups of drugs can act synergistically.