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目的评价早期乳腺癌保乳术后调强适形放疗(IMRT)的疗效。方法计算机检索中文科技期刊全文数据库、中国期刊全文数据库、数字化期刊全文数据库、中国生物医学文献数据库、PubMed、Cochrane Library、SCI及EMBASE数据库,并辅手工检索和其他检索。纳入比较早期乳腺癌保乳术后调强适形放疗与传统放疗(RT)的随机对照试验,根据Cochrane系统评价手册5.0.0质量评价标准进行质量评价,使用RevMan5.0软件进行Meta分析。结果共纳入4个研究(1 440例)。Meta分析显示,与RT相比,IMRT可降低急性湿性皮炎、乳房浮肿和色素沉着的发生。结论IMRT可明显降低急性湿性皮炎的发生,减轻患者痛苦,提高生活质量。
Objective To evaluate the efficacy of intensity modulated radiotherapy (IMRT) after breast conserving surgery in early breast cancer. Methods The full-text databases of Chinese scientific journals, Chinese periodicals full-text databases, digital periodicals full-text databases, Chinese biomedical literature databases, PubMed, Cochrane Library, SCI and EMBASE databases were retrieved by computer and assisted by hand and other searches. A randomized, controlled trial of intensity-modulated radiotherapy and conventional radiotherapy (RT) after breast-conserving surgery was included in the study. The quality was evaluated according to the 5.0.0 Quality Evaluation Criteria of Cochrane System Evaluation Manual, and Meta-analysis was performed using RevMan 5.0 software. Results A total of 4 studies (1440) were included. Meta-analysis showed that IMRT reduced acute dermatitis, breast edema and pigmentation in comparison to RT. Conclusion IMRT can significantly reduce the incidence of acute dermatitis, reduce pain and improve quality of life.