RhoA signaling and blood pressure:The consequence of failing to“Tone it Down”

• 作 者: Xue Bai Rachel Dee Kevin D Man
• 机 构: DepartmentofPathologyandLaboratoryMedicine
• 出 处: 世界高血压杂志
• 发表日期: 2016年1期
• 关键词: Hypertension Blood pressure RHOA Smooth muscle CONTRACTION GUANINE NUCLEOTIDE ex
• 基金项目: Supported by the National Heart,Lung,and Blood Institute,National Institutes of Health to Taylor JM,Nos.HL-081844 and HL-071054,and the Muscular Dystrophy Association to Taylor JM,No.MDA255577.

Uncontrolled high blood pressure is a major risk factor for heart attack,stroke,and kidney failure and contributes to an estimated 25%of deaths worldwide.Despite numerous treatment options,estimates project that reasonable blood pressure(BP)control is ach