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目的观察多普勒超声联合β-人绒毛膜促性腺激素(β-h CG)检测对评估妊娠滋养细胞疾病(GTD)的临床意义。方法选取医院收治的GTD患者124例,均通过病理学检查确诊,且接受多普勒超声联合β-h CG检测,比较超声诊断准确率及良恶性病变、恶性病变治疗前后血清中β-h CG水平、血窦内阻力指数(RI)。结果超声诊断显示良性病变诊断准确率为96.36%(53/55),恶性病变诊断准确率为100.00%(69/69);与良性病变比较,恶性病变血清中β-h CG水平较高,血窦内RI较低,差异有统计学意义(P<0.05);与治疗前比较,治疗后患者血清中β-h CG水平较低,血窦内RI较高,差异有统计学意义(P<0.05)。结论多普勒超声诊断GTD具有较高准确性,且与血清β-h CG联合检测,可有效评估患者病情程度。
Objective To observe the clinical significance of Doppler ultrasound and β-human chorionic gonadotropin (β-h CG) in the evaluation of gestational trophoblastic disease (GTD). Methods Totally 124 patients with GTD admitted to our hospital were diagnosed by pathological examination and were examined by Doppler ultrasound combined with β-h CG. The diagnostic accuracy of ultrasound and benign and malignant lesions were compared. The serum levels of β-h CG Level, sinusoidal resistance index (RI). Results The diagnostic accuracy rate of benign lesions was 96.36% (53/55), and the diagnostic accuracy of malignant lesions was 100.00% (69/69). Compared with benign lesions, the serum levels of β-h CG in malignant lesions were higher than those in benign lesions The intra-sinus RI was lower, the difference was statistically significant (P <0.05). Compared with before treatment, the level of β-h CG in serum was lower and RI in sinusoid was higher, the difference was statistically significant (P < 0.05). Conclusion Doppler ultrasound diagnosis of GTD with high accuracy, and serum β-h CG joint detection, which can effectively assess the patient’s condition.