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·AIM: To determine the effects of laser photocoagulation on serum levels of angiopoietin-1(Ang-1),angiopoietin-2(Ang-2), soluble angiopoietin receptor Tie-2(Tie-2), Ang-1/Ang-2 ratio and vascular endothelial growth factor(VEGF) in patients with type 2diabetes mellitus(T2DM) and proliferative diabetic retinopathy(PDR). We also explored the role of the Ang/Tie system in PDR.·METHODS:Totally 160patientswithT2 DM, including50 patients with non-diabetic retinopathy(NDR), 58 patients with non-proliferative diabetic retinopathy(NPDR), and52 patients with PDR were enrolled in this study. Serum Ang-1, Ang-2, Tie-2 receptor and VEGF levels were measured using enzyme-linked immunosorbent assays for all patients and were repeated in 26 patients who underwent laser photocoagulation two months after the procedure.·RESULTS:ThemedianlevelsofAng-2andVEGFinserum were significantly higher in the NPDR group(4.23 ng/mL and 303.2 pg/mL, respectively) compared to the NDR group(2.67 ng/mL and 159.8 pg/mL, respectively, P <0.01), with the highest level in the PDR group(6.26 ng/mL and531.2 pg/mL, respectively, P <0.01). The median level of Ang-1 was significantly higher in the NPDR group(10.77ng/mL) compared to the NDR group(9.31 ng/mL) and the PDR groups(9.54 ng/mL)(P <0.05), while no difference was observed between the PDR and NDR groups. Ang-1/Ang-2 ratio of PDR group was lowest in three groups(1.49 vs 2.69 and 2.90, both P <0.01). The median level of Tie-2was not significantly different among three groups(P >0.05).Ang-2 was positively correlated with VEGF and Tie-2 in the PDR and NPDR groups(both P <0.05). Among the 26 patients who underwent laser photocoagulation, serum Ang-2 and VEGF levels significantly decreased(both P <0.05), whereas serum Ang-1 level and Ang-1/Ang-2ratio were weakly increased(P >0.05). The median levels of Ang-2 and VEGF in serum were highest in PDR group,however, Ang-1/Ang-2 ratio of PDR group was lowest in three groups.·CONCLUSION: Laser photocoagulation can reduce serum Ang-2 and VEGF levels. The Ang/Tie system and VEGF play an important role in the development and progression of T2 DM patients with PDR.
· AIM: To determine the effects of laser photocoagulation on serum levels of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), soluble angiopoietin receptor Tie-2, Ang-1 / Ang- 2 ratio and vascular endothelial growth factor (VEGF) in patients with type 2 diabetes mellitus (T2DM) and proliferative diabetic retinopathy (PDR). We also explored the role of the Ang / Tie system in PDR. METHODS: Totally 160 patients with T2 DM, including 50 patients with non-proliferative diabetic retinopathy (NDR), 58 patients with non-proliferative diabetic retinopathy (NPDR), and 52 patients with PDR were enrolled in this study. Serum Ang-1, Ang- 2, Tie- 2 receptor and VEGF levels were measured using enzyme-linked immunosorbent assays for all patients and were repeated in 26 patients who underwent laser photocoagulation for two months after the procedure. RESULTS: The median levels of Ang-2 and VEGF F wereser in higher the NPDR group (4.23 ng / mL and 303.2 pg / mL, respectively) compared to the NDR group (2.67 ng / mL and 159.8 pg / mL, respectively, P <0.01), with the highest level in the PDR group (6.26 ng / mL and 531.2 pg / mL, respectively, P <0.01). The median level of Ang-1 was significantly higher in the NPDR group ng / mL compared to the NDR group (9.31 ng / mL) and the PDR groups (9.54 ng / mL) (P <0.05) while no difference was observed between the PDR and NDR groups. Ang-1 / Ang-2 The median level of Tie-2 was not significantly different among three groups (P> 0.05). Ang-2 was positively correlated with VEGF and Tie-2 in the PDR and NPDR groups (both P <0.05). Among the 26 patients who underwent laser photocoagulation, serum Ang-2 and VEGF levels significantly decreased (both P <0.05) 1 / Ang-2 ratio was weakly increased (P> 0.05). The median levels of Ang-2 and VEGF in serum were highest in PDR group, however, Ang- 1 / Ang- 2 ratio of PDR group was lowest in three groups. CONCLUSION: Laser photocoagulation can reduce serum Ang-2 and VEGF levels. The Ang / Tie system and VEGF play an important role in the development and progression of T2 DM patients with PDR.