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目的：了解难治性肺结核的耐药特征，为结核病防治提供参考依据。方法：改良罗氏培养基绝对浓度法。结果：１３６例慢性排菌肺结核病人分别对两种或以上主要抗结核药物耐药，其综合耐药率为１００％，其中以耐链霉素、利福平及异烟肼为主，乙胺丁醇、卡那霉素次之，对氟嗪酸也有一定程度的耐药性。结论：对慢性排菌病人的治疗应认真参考药敏结果，慎重选择敏感的药物组合治疗方案，不宜机械地制定“统一”的化疗方案，尽可能避免敏感药物的继发性耐药。
Objective: To understand the drug resistance characteristics of refractory pulmonary tuberculosis and provide a reference for the prevention and treatment of tuberculosis. Methods: The modified Roche medium absolute concentration method. Results: 136 cases of chronic pulmonary tuberculosis patients were resistant to two or more major anti-TB drugs, the comprehensive resistance rate was 100%, of which streptomycin, rifampicin and isoniazid-based, ethylamine Butanol, followed by kanamycin, there is a certain degree of resistance to flufenamic acid. Conclusion: The treatment of patients with chronic row bacteria should carefully consider the drug susceptibility results, carefully select the sensitive drug combination regimen, should not mechanically formulate a “unified” chemotherapy regimens, as far as possible to avoid the secondary drug-resistant susceptibility.