拉莫三嗪添加治疗儿童癫(癎)性脑病的疗效观察

• 作 者: 俞宏真 王治平 陈莹
• 机 构: 上海交通大学医学院附属上海儿童医学中心,上海交通大学医学院附属上海儿童医学中心,上海交通大学医学院附属上海儿童医学中心,
• 出 处: 临床神经电生理学杂志
• 发表日期: 2007年01期
• 关键词: 拉莫三嗪 添加治疗 癫(癎)

目的:评估拉莫三嗪(LTG)作为添加药物治疗儿童癫癎性脑病(Lennox-Gastaut syn- drome,LGS)的有效性。方法:研究是单中心、回顾性,对于18例用其他抗癫癎药物治疗发作控制不佳的LGS患儿,加用LTG治疗,观察其发作频率的减少程度。结果:61％的患儿对LTG添加治疗有效,抽搐发作减少程度与发作类型有关,主要表现为肌阵挛性发作的治疗效果最差,而主要表现为失神发作和(或)部分性发作类型的治疗效果较佳。结论:LTG添加治疗LGS患儿,对减少发作次数有一定效果,但疗效与主要发作类型相关。

PURPOSE: To evaluate the efficacy of lamotrigine (LTG) as an adjunctive drug in the treatment of childhood Lennox-Gastaut syn- drome (LGS). METHODS: The study was a single-center, retrospective study of 18 children with LGS who had poorly controlled seizures with other antiepileptic drugs plus LTG and observed the reduction in seizure frequency. RESULTS: Sixty-one percent of children treated with LTG were effective in reducing the incidence of seizures and the type of seizure. The main findings were the least effective treatment of myoclonic seizures and the main manifestations of absence seizures and / or partial seizure types The treatment effect is better. CONCLUSIONS: The addition of LTG to children with LGS has some effect in reducing the number of episodes, but the effect is related to the main type of attack.