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PIWI家族成员包含保守的PAZ和PIWI区域,在干细胞自我更新、精子发生、RNA干扰和翻译调控中扮演重要角色。最近研究发现,一些PIWI在肿瘤中呈特异性表达,并与肿瘤的发生、发展相关。PIWI将有可能成为肿瘤诊断和预后判断的一个新的重要指标。研究PIWI表达调控机制,可探讨PIWI在肿瘤基因治疗方面的可行性。
The PIWI family members contain conserved PAZ and PIWI regions and play an important role in stem cell self-renewal, spermatogenesis, RNA interference and translational regulation. Recent studies have found that some PIWIs are specifically expressed in tumors and are associated with tumorigenesis and development. PIWI will likely become a new important indicator of tumor diagnosis and prognosis. To investigate the mechanism of PIWI expression and to explore the feasibility of PIWI in the gene therapy of cancer.