论文部分内容阅读
目的:观察蒺藜皂苷(GSTT)对麻醉开胸犬血流动力学和氧代谢的影响。方法:实验犬30只随机分为5组(每组6只):生理盐水对照组、血塞通(阳性对照药物)组及GSTT低、中、高剂量(6.26、12.52和25.00 mg.kg-1)组。采用静脉注射给药方式,检测血流动力学和氧代谢各项指标。结果:GSTT低、中及高剂量组犬心肌血流量高于对照组(P<0.01),平均动脉压、冠脉阻力、总外周血管阻力低于对照组(P<0.05或P<0.01),心肌耗氧量、心肌耗氧指数及心肌氧摄取率低于对照组(P<0.05或P<0.01)。结论:GSTT对麻醉开胸犬心脏功能有明显的调节和改善作用。
Objective: To observe the effects of GSTT on hemodynamics and oxygen metabolism in anesthetized thorax dogs. METHODS: Thirty experimental dogs were randomly divided into 5 groups (n=6 per group): saline control group, Xuesaitong (positive control drug) group, and GSTT low, medium, and high doses (6.26, 12.52, and 25.00 mg.kg- Group 1. Intravenous injections were used to test hemodynamics and oxygen metabolism indicators. RESULTS: Myocardial blood flow of GSTT low, medium and high dose group was higher than that of control group (P<0.01). Mean arterial pressure, coronary resistance, and total peripheral vascular resistance were lower in the GSTT group than in the control group (P<0.05 or P<0.01). Myocardial oxygen consumption, myocardial oxygen consumption index, and myocardial oxygen uptake rate were lower than those in the control group (P<0.05 or P<0.01). Conclusion: GSTT can obviously regulate and improve the heart function of anesthetized open-heart dogs.