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胡萝卜籽挥发油对小鼠有抗着床,抗早、中和晚期妊娠作用。对大鼠也有抗着床作用。挥发油中的萜类碳氢化合物部位,对小鼠皮下注射抗早期妊娠的ED_(50)为2.9ml/kg,甲地孕酮和hCG能明显逆转其作用;对假孕小鼠蜕膜瘤有抑制作用,此作用不能被甲地孕酮拮抗,皮下注射于早孕大鼠24、48小时后血浆孕酮浓度明显下降。以上提示其抗早孕作用机制可能与抑制孕酮合成和蜕膜反应有关。此外,挥发油碳氢部分无雌激素和抗雌激素活性,低浓度时对早孕大鼠离体子宫的收缩活动没有影响,高浓度则表现抑制作用。
Carrot seed oil has anti-implantation in mice, anti-early, middle and late pregnancy effect. Anti-implantation effect on rats also. Volatile oil in the terpene hydrocarbon parts of mice subcutaneous injection of anti-early pregnancy ED_ (50) was 2.9ml / kg, megestrol and hCG megestrol can reverse its role in pregnancy; Inhibition, this effect can not be antagonized by megestrol, subcutaneous injection in early pregnancy 24,48 hours after the plasma progesterone concentrations decreased significantly. The above suggests that its anti-early pregnancy mechanism may be related to inhibition of progesterone synthesis and decidual reaction. In addition, the volatile oil hydrocarbon part of the estrogen and anti-estrogen activity, low concentration of uterine contractions in early pregnancy rats had no effect on activity, high concentrations showed inhibitory effect.