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据J Clin pharmacol(1993.33:213)文载S Kacew报告,授乳期用药,尽管仅1～2％进入母乳,但对乳幼儿可能有潜在的危害。 母乳中药物进入量与下列因素有关:母体内的生物利用度、用药次数和途径、母体内药代动力学、乳房血流量和pH值和母乳生成率。如果母体营养不良,药物代谢下降或进入母乳的药物量增多。 药物的理化特性,即离子化程度、分子量、脂溶性和与蛋白质结合的能力等也影响从母乳中分泌的程度。授乳后用药或以吸入的方式用药可减少母乳
According to J Clin Pharmacol (1993.33: 213), S Kacew reports that breast-feeding medication, while only 1-2% entering breast milk, may be potentially harmful to young children. The amount of drug intake in breast milk is related to the following: the bioavailability in the mother, the frequency and route of administration, the pharmacokinetics in the mother, the blood flow and pH in the breast, and the rate of breast milk formation. If maternal malnutrition, drug metabolism decreased or the amount of drug into breast milk increased. Physicochemical properties of the drug, ie, the degree of ionization, molecular weight, liposolubility and ability to bind to the protein, also affect the degree of secretion from breast milk. After breast-feeding or inhaled medication can reduce breast milk