论文部分内容阅读
目的探讨血清的微量元素水平在健康人、胃癌,非癌症患者中变化的临床意义。方法对27例胃癌患者(胃癌组)、50例健康体检者(健康对照组)及40例非癌症但患有消化道疾病患者(非癌症对照组)采用原子吸收光谱法测定血清中各种微量元素包括铜、锌、铁、镁水平及铜/锌比值5项指标。结果健康对照组血清铜、锌、铁、镁水平分别为(0.877±0.235)mg.L-1、(2.809±0.898)mg.L-1、(13.353±4.232)mg.L-1和(21.801±2.980)mg.L-1;铜/锌比值为0.337±0.121。胃癌组与非癌症对照组比较:血清中铜水平升高明显(P<0.01),分别为(1.183±0.194)mg.L-1和(0.892±0.195)mg.L-1,铜/锌比值明显增高(P<0.01),分别为0.535±0.165和0.348±0.127,血清中铁水平明显降低,分别为(10.779±4.227)mg.L-1和(12.931±3.778)mg.L-1;胃癌组与健康对照组比较:锌水平明显降低(P<0.05)[(2.392±0.717)mg.L-1],镁水平显着升高(P<0.01)[(24.274±3.636)mg.L-1]。结论血清中铜水平升高、铜/锌比值增加及铁水平的降低是胃癌的危险因素,具有临床意义。
Objective To investigate the clinical significance of serum trace element levels in healthy people, gastric cancer and non-cancer patients. Methods Twenty-seven gastric cancer patients (gastric cancer group), 50 healthy subjects (healthy control group) and 40 non-cancer patients with digestive diseases (non-cancer control group) Elements include copper, zinc, iron, magnesium levels and copper / zinc ratio of 5 indicators. Results The levels of copper, zinc, iron and magnesium in the healthy control group were (0.877 ± 0.235) mg.L-1, (2.809 ± 0.898) mg.L-1, (13.353 ± 4.232) mg.L- ± 2.980) mg.L-1; the copper / zinc ratio was 0.337 ± 0.121. Compared with the non-cancerous control group, the level of copper in serum increased significantly (P <0.01), and the difference was (1.183 ± 0.194) mg.L-1 and (0.892 ± 0.195) mg.L- (10.779 ± 4.227) mg.L-1 and (12.931 ± 3.778) mg.L-1 respectively in gastric cancer group (P <0.01), which were 0.535 ± 0.165 and 0.348 ± 0.127 respectively Compared with the healthy control group, the level of zinc was significantly decreased (P <0.05) [(2.392 ± 0.717) mg.L-1] and the level of magnesium was significantly increased (P <0.01) [(24.274 ± 3.636) mg.L- ]. Conclusion The serum copper levels, copper / zinc ratio and iron levels decreased risk factors for gastric cancer, with clinical significance.