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目的:为了评价急性淋巴细胞性白血病(ALL)患儿在应用皮质类固醇和其他细胞毒性药物诱导治疗后的肾上腺功能。研究设计:ALL患儿(n=24)在诱导期应用强的松龙28d,40mg/(m2·d),然后每4周口服地塞米松1周。在强的松龙停止2周时进行小剂量(1μg)促肾上腺皮质激素(ACTH)试验,在2周后再重复此试验并对有肾上腺抑制的患儿每4周重复进行,直至获得正
Objective: To evaluate adrenal function in children with acute lymphoblastic leukemia (ALL) after induction therapy with corticosteroids and other cytotoxic drugs. Study design: ALL children (n = 24) were given prednisolone 28d, 40mg / (m2 · d) during the induction phase and then dexamethasone for 1 week every 4 weeks. A small dose (1 μg) of adrenocorticotrophic hormone (ACTH) test was performed at 2 weeks after the prednisolone was stopped, and this trial was repeated two weeks later and the child with adrenal suppression was repeated every four weeks until a positive