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已有数篇报道提出大环内酯类抗生素如红霉素、三乙酰夹竹桃霉素对慢性哮喘患者临床状况具良好效用,其机制曾被认为并非抗微生物效应,而系药物的少许类固醇效应作用于类固醇依赖性哮喘的结果。一些研究者搞清了红霉素本身有抗炎作用,但能否改善哮喘患者的支气管反应性仍不明了。作者评价红霉素对非类固醇依赖性哮喘患者对支气管高反应性的作用.支气管哮喘患者23例,以皮肤划痕试验结果分为变应型与非变应型两组,并进行了组织胺吸入激发试验,确定使FEV_1下降20%时组织胺的浓度值(PC20).初次吸入后,对患者进行10周的口服红霉素治疗,200mg tid,停用红霉素24小时后再重复
There have been several reports suggesting that macrolide antibiotics such as erythromycin and triacetyl oleandomycin have a good effect on the clinical status of patients with chronic asthma and the mechanism was considered not antimicrobial effect but rather a small steroid effect Effect on steroid-dependent asthma. Some researchers have figured out that erythromycin itself has an anti-inflammatory effect, but it remains unclear whether it will improve bronchial responsiveness in asthmatics. The authors evaluated the effect of erythromycin on bronchial hyperreactivity in patients with non-steroid-dependent asthma.23 patients with bronchial asthma were divided into allergic and non-allergic skin scratch test results and histamine Inhalation challenge test was performed to determine histamine concentration (PC20) at a 20% fall in FEV 1. After initial inhalation, the patient was treated with oral erythromycin for 10 weeks, 200 mg tid, and erythromycin for 24 hours