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通过固定化酶Novozyme435(NV435)催化聚乙二醇(PEG)开环聚合己内酯(CL)得到端基带有羟基的ABA型三嵌段聚合物,用2,2-二氯代乙酰氯将聚合物的端羟基功能化形成H型大分子引发剂,在CuCl/HMTETA体系中引发4-乙烯基吡啶(4VP)进行原子转移自由基聚合反应(ATRP),得到了具有两亲性的H型五嵌段聚合物(PVP)2-b-PCL-b-PEG-PCL-(PVP)2,用红外光谱(FT IR),核磁共振(1H NMR),凝胶渗透色谱(GPC)对其结构与分子量及其分子量分布进行了表征,结果表明:H型五嵌段聚合物分子量46121g/mol,分子量分布1.30.并利用动态光散射(DLS)和原子力显微镜(AFM)对聚合物在水溶液中的自组装行为进行了研究,H型嵌段聚合物的胶束呈球形结构,平均直径为70nm左右.
Polymerization of caprolactone (CL) with polyethylene glycol (PEG) catalyzed by immobilized enzyme Novozyme435 (NV435) gave an ABA-type triblock polymer with hydroxyl groups at the end and 2,2-dichloroacetyl chloride The terminal hydroxyl groups of the polymers were functionalized to form H-type macroinitiators. Atom transfer radical polymerization (ATRP) of 4-vinylpyridine (4VP) was initiated in CuCl / HMTETA system to obtain amphiphilic H type (PVP) 2-b-PCL-b-PEG-PCL- (PVP) 2 was synthesized and characterized by FT-IR, 1H NMR and GPC. The results showed that the molecular weight of H-type five-block polymer was 46121g / mol and the molecular weight distribution was 1.30. The effects of dynamic light scattering (DLS) and atomic force microscopy (AFM) The self-assembly behavior was studied. The micelles of H-type block polymers were spherical with an average diameter of about 70 nm.