论文部分内容阅读
[目的]探讨亚甲基四氢叶酸还原酶(MTHFR)C677T基因多态性与原发性肝癌患者肝动脉化学治疗栓塞术(TACE)疗效的关系.[方法]给125例原发性肝癌患者行TACE治疗,其中63例给予复方碘油加顺铂(DDP)、吡柔比星(THP)和丝裂霉素(MMC)混悬剂灌注;62例给予复方碘油加DDP,THP及5-氟脲嘧啶(5-FU)混悬剂.经行2次TACE治疗后进行临床疗效评价.采用Real-time PCR检测MTHFRC677T基因多态性,分析不同基因型与TACE治疗疗效的关系.[结果]125例患者的总有效率为35.2%,其中复方碘油混合DDP,THP及MMC治疗组有效率为38.1%,复方碘油混合DDP,THP及5-FU治疗组有效率为32.3%,两者间差异无统计学意义(P=0.494).MTHFR C677T基因多态性与2种TACE治疗均无相关性.[结论]MTHFR C677T基因多态性对肝癌TACE常用药物的敏感性无影响.
[Objective] To investigate the relationship between methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and efficacy of transcatheter arterial chemoembolization (TACE) in patients with primary liver cancer. [Methods] Sixty-two patients were given TACE and DDP, THP and mitomycin (MMC) were infused in 63 cases. DDP, THP and 5 - fluorouracil (5-FU) suspension.After two TACE treatments, the clinical efficacy was evaluated.METHODS MTHFRC677T gene polymorphism was detected by Real-time PCR and the relationship between different genotypes and the therapeutic effect of TACE was analyzed.Results ] The total effective rate of 125 patients was 35.2%. The effective rate of compound lipiodol mixed DDP, THP and MMC was 38.1%, and the effective rate of compound lipiodol mixed DDP, THP and 5-FU was 32.3% There was no significant difference between the two groups (P = 0.494) .MTHFR C677T gene polymorphism had no correlation with the two kinds of TACE treatment. [Conclusion] The polymorphism of MTHFR C677T gene has no effect on the sensitivity of TACE common drugs for liver cancer.