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目的分析单用化疗或化疗联合伊班膦酸钠治疗肺癌骨转移的疗效。方法共68例患者,分两组治疗。34例单用NP方案化疗:诺维本25 mg/m2,第1、8天静脉推注,顺铂20 mg第1~5天静脉点滴,以21 d为一周期。34例化疗联合艾本治疗:NP方案化疗(方法同前),加艾本4 mg/次,21 d为一周期。均连用2周期。然后评价疗效。结果单用化疗组,疼痛缓解率82.3%(28.34),化疗联合艾本组,疼痛缓解率100%(34.34)。结论化疗联合艾本对肺癌骨转移疗效好,能缓解疼痛,延长生存期。艾本不良反应轻,是临床值得推广的新一代双膦酸盐药物。
Objective To analyze the efficacy of chemotherapy alone or chemotherapy combined with ibandronate in the treatment of bone metastases of lung cancer. Methods A total of 68 patients were divided into two groups. 34 cases of chemotherapy with NP alone: novibben 25 mg / m2, intravenous injection on the first and second day, cisplatin 20 mg intravenous drip on the first day to the fifth day to 21 d for a cycle. 34 cases of chemotherapy combined with Ai Ben treatment: NP chemotherapy (with the same method), add Benben 4 mg / time, 21 d for a cycle. Are used even 2 cycles. Then evaluate the efficacy. Results In the chemotherapy alone group, the pain relief rate was 82.3% (28.34). The pain relief rate was 100% (34.34). Conclusions Chemotherapy combined with Alban is effective in treating bone metastases of lung cancer and can relieve pain and prolong survival. Avery adverse reactions, is a new generation of clinical bisphosphonate drugs worth promoting.