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前文报道了光、温度等环境因素对辅酶Q_10注射液含量的影响,采取避光(主要指直射阳光和散射光),以及在阴凉处贮藏,可改善其稳定性,延长有效期。但我们在留样观察中发现,注射液室温贮存一年以内,含量一般降至90％以下,贮藏1～3个月左右,绝大多数样品有辅酶Q_10黄色沉淀析出,且pH值有不同程度的下降(灭菌后pH下降幅度较大,贮藏过程中pH也有下降),不适应药品的临床使
The previous article reported the light, temperature and other environmental factors on the content of coenzyme Q_10 injection, to take light (mainly refers to direct sunlight and scattered light), and stored in the shade, can improve its stability and extend the validity. However, we observed in stay samples found that the injection room temperature storage within one year, the content generally dropped below 90%, storage for 1 to 3 months, the vast majority of samples coenzyme Q_10 yellow precipitation, and the pH value of varying degrees Decline (pH drop after sterilizing large, pH also decreased during storage), does not meet the clinical use of drugs