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溴丙胺太林(普鲁本辛)是人工合成的抗毒蕈碱四元化合物,临床上主要用于治疗消化性溃疡和痉挛性排尿困难。作者研究了食物对溴丙胺太林生物利用度的影响,他们按下列方式分别给10名受试者用药(30mg),1、静脉注射,2、禁食12h后口服片剂(2×15mg),3、进标准早餐后口服摄入。随后采集受试者的血样进行分析。结果发现禁食和进餐后血药浓度的峰值分别是9.1μg/ml和3.1μg/ml(均值),而相应的达峰时间为1.03h和1.95n。此外,禁食后血药浓度曲线下的面积(AUC)约为进餐后的3倍。研究结果表明食物会降低溴丙胺太林生物利用度的吸收速度和广度。同时他们还发现禁食后
Bromopropylamine too forest (Prümbutin) is a synthetic anti-muscarinic quaternary compounds, clinically used mainly for the treatment of peptic ulcer and spasmodic dysuria. The authors studied the effects of food on the bioavailability of Bromopyramide, who were given 10 mg (30 mg), 1, iv, 2, and orally administered tablets (2 × 15 mg) after 12 h of fasting in the following manners: 3, into the standard after oral intake of breakfast. The subject’s blood samples are then collected for analysis. As a result, the peak values of fasting and postprandial plasma concentrations were found to be 9.1 μg / ml and 3.1 μg / ml, respectively, with corresponding peak times of 1.03 h and 1.95 n. In addition, the area under the fasting plasma concentration curve (AUC) was about three times after meal. The results show that food reduces the rate and breadth of bioavailability of Bromopylamine. At the same time they also found after fasting