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选择性钙通道站抗剂非洛地平以（felodipine，1）是一种强效的血管舒张剂，临床上用于治疗高血压。由于极性相似，非洛地手难以通过普通的TLC或硅胶柱色谱分离与合成中产生的对称的二甲酯和二乙酯杂质分离。本文作者使用极性较高的（2-氰基乙基）酯代替原来的3－氨基巴豆酸甲酯
Selective calcium channeling agent felodipine (felodipine, 1) is a potent vasodilator that is clinically used to treat high blood pressure. Because of their similarities, felodipine is difficult to separate from the symmetrical dimethyl- and diethyl-ester impurities produced by the synthesis by conventional TLC or silica gel column chromatography. The authors used the more polar (2-cyanoethyl) ester instead of the original methyl 3-aminocrotonate