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目的探讨拉莫三嗪(LTG)添加治疗难治性癫癎的疗效和安全性。方法难治性癫癎68例.以开始治疗前3个月患儿平均每月发作次数为基线,与LTG治疗3个月后平均每月发作次数比较。按常规计算完全控制率和有效率。并进行临床观察。结果完全控制率27.9%;有效率544%。19例次出现不良反应,但大部分症状轻微,可自行消失。结论LTG添加治疗儿童难治性癫癎疗效显著,安全性好。
Objective To investigate the efficacy and safety of lamotrigine (LTG) in the treatment of refractory epilepsy. Methods 68 cases of refractory epilepsy.At the beginning of the first three months before treatment, the average number of monthly seizures as the baseline, and LTG treatment after 3 months compared to the average monthly seizures. Calculate the full control rate and efficiency routinely. And clinical observation. The results of complete control rate of 27.9%; effective rate of 544%. Nineteen adverse reactions occurred, but most of the symptoms were mild and disappeared on their own. Conclusion The treatment of refractory childhood epilepsy with LTG is effective and safe.