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目的了解噻庚啶对多脏器功能失常综合征（ＭＯＤＳ）大鼠的防治作用，并揭示给药时间与防治效果之间的关系。方法用ＳＤ大鼠制作ＭＯＤＳ模型，观察噻庚啶及给药时间对血清相关生化指标的影响。结果噻庚啶保护组和非保护组比较，血清中超氧化物歧化酶（ＳＯＤ）、谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性明显升高（Ｐ＜０．０５），丙二醛（ＭＤＡ）含量显著降低（Ｐ＜０．０５）；同时血清丙氨酸氨基转移酶（ＡＬＴ）、肌酸激酶（ＣＫ）和肌酐（Ｃｒ）均有相应的降低，且早期给药保护组与对照组比较差异有显著性意义（Ｐ＜０．０５），而晚期给药保护组与对照组比较差异无显著性意义（Ｐ＞０．０５）。结论噻庚啶能清除氧自由基，减轻细胞损伤和多器官功能衰竭；早期给药对保护重要脏器的功能有利。
Objective To investigate the preventive and therapeutic effects of thienopyrimidine on multiple organ dysfunction syndrome (MODS) rats and to reveal the relationship between the administration time and the prevention and treatment effect. Methods MODS model was made in SD rats to observe the influence of thienopyrimidine and administration time on serum related biochemical indexes. Results Compared with non-protective group, the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were significantly increased (P <0.05) (P <0.05). At the same time, serum alanine aminotransferase (ALT), creatine kinase (CK) and creatinine (Cr) There was significant difference between the control group and the control group (P <0.05), but there was no significant difference between the late drug administration group and the control group (P> 0.05). Conclusion Thiengidine can scavenge oxygen free radicals, reduce cell damage and multiple organ failure; early administration is beneficial to the protection of vital organs.