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DNA序列的变异是所有肿瘤细胞发生的重要的分子层面的原因,目前学术界已经有能力对一定规模的癌症队列样本开展全基因组变异图谱的分析.国际肿瘤基因组协作联盟(ICGC)于2007年成立并启动了全球范围的肿瘤基因组研究工作.ICGC提出对50种癌症,总计25000例患者样本绘制体细胞基因突变谱.多个国家的参与课题组已经阶段性地总结了特定癌症的数据并报道了研究成果,当前跨癌种的泛癌症基因组的研究已经成为ICGC的工作重点.我国以中国肿瘤基因组协作组(CCGC)的形式参与了ICGC的合作研究,选择包括食管癌、胃癌、肝癌、大肠癌、鼻咽癌等13种癌症并取得相关进展.CCGC和ICGC研究工作将积极推动癌症基因组学向肿瘤生物学的转化研究,为肿瘤的个体化精准诊疗提供理论和技术支撑.
DNA sequence variation is an important molecular aspect of the development of all tumor cells and the academic community has now been able to analyze genome-wide variation maps of a limited number of cancer cohort samples. The International Cancer Genome Union (ICGC) was established in 2007 And started a global cancer genome research work.ICCC proposed 50 kinds of cancer, a total of 25,000 patient samples drawn somatic gene mutation spectrum.Multiple countries participating task groups have been summarized in a particular cancer data and reported According to the research results, the current research on the pan-cancer genome of transplanted cancer has become the focus of ICGC.China has participated in the cooperative research of ICGC in the form of China Cancer Genome Collaborative Group (CCGC), including esophageal cancer, gastric cancer, liver cancer, colorectal cancer , Nasopharyngeal carcinoma and other 13 kinds of cancer and make relevant progress.CCGC and ICGC research work will actively promote the transformation of cancer genomics to tumor biology research to provide theoretical and technical support for the individualized diagnosis and treatment of cancer.