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目的:探讨高渗盐水对危重症手足口病患儿钠离子浓度的影响并观察其疗效。方法:选择危重症手足口病患儿63例,随机分为治疗组和对照组,两组均使用常规镇静、止痉、降颅压、抗病毒等治疗,治疗组加用高渗盐水。比较两组治疗前后血清钠离子浓度、危重评分、转归情况。结果:治疗后治疗组血清钠离子浓度、小儿危重症评分均较对照组显著增高,差异有统计学意义(P<0.05);治疗效果优于对照组,差异有统计学意义(P<0.05)。结论:危重症手足口病患儿使用高渗盐水可在短时间内提高钠离子浓度,远期改善患儿预后,是一种安全有效的治疗方法。
Objective: To investigate the effect of hypertonic saline on sodium ion concentration in children with critically ill hand-foot-mouth disease and to observe its curative effect. Methods: 63 critically ill children with hand-foot-mouth disease were randomly divided into treatment group and control group. Both groups were treated with routine sedation, antispasmodic, intracranial pressure reduction and antiviral therapy. The treatment group was given hypertonic saline. Serum sodium concentration, risk score and outcome were compared between the two groups before and after treatment. Results: After treatment, serum sodium concentration and pediatric critical illness score were significantly higher in the treatment group than those in the control group (P <0.05), and the treatment effect was better than that in the control group (P <0.05) . Conclusion: The use of hypertonic saline in critically ill hand-foot-mouth disease patients can increase the sodium ion concentration in a short time and improve the prognosis of the children in the long-term, which is a safe and effective treatment.