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测定细胞内镁浓度很重要,因镁大多数在细胞内并在细胞内代谢,在胞浆、线粒体、内质网和细胞膜发生代谢活动。这些功能发生改变时引起临床疾病。离子化镁是调节大多数细胞功能的必需成分。本文专述镁对心血管系统的分子和细胞作用及这些作用与镁改变的临床表现之间的联系。对心肌收缩性的分子及细胞作用镁对心肌代谢的影响包括收缩性和电活性两方面,两者密切相联。Page和Polimeni测定了大鼠心室肌细胞Mg~(2+)含量及分布,约12％心肌Mg~(2+)在线粒体内,2—3％在肌原纤维内,大部分与ATP、ADP、AMP在一起。细胞内游离镁浓度为1mmol/L或以下,Mg~(2+)可能是一种生理调节剂。镁对心肌收缩性的影响是由于它能在几方面影响
Determination of intracellular magnesium concentration is important because magnesium is mostly intracellular and metabolized in the cell and undergoes metabolic activity in the cytoplasm, mitochondria, endoplasmic reticulum and cell membrane. Changes in these functions cause clinical problems. Magnesium ion is an essential ingredient that regulates most cellular functions. This article describes the molecular and cellular effects of magnesium on the cardiovascular system and the link between these effects and the clinical manifestations of altered magnesium. Molecular and cellular effects on myocardial contractility Effects of magnesium on myocardial metabolism include contractility and electrical activity, both of which are closely linked. Page and Polimeni determine the content and distribution of Mg 2+ in ventricular myocytes of rats, about 12% of the myocardium Mg 2+ in the mitochondria, 2-3% in the myofibrils, mostly with ATP, ADP AMP together. Intracellular free magnesium concentration of 1mmol / L or less, Mg ~ (2+) may be a physiological regulator. The effect of magnesium on myocardial contractility is due to its impact in several ways