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为确定牛肺表面活性剂（开塞肺）临床用药的安全性，在大鼠、家兔对开塞肺进行了局部刺激实验、急性毒性实验、长期毒性实验。结果表明开塞肺是一种较为安全的制剂，常规剂量气管内滴入不会有毒性作用，多次或大剂量气管内给药可导致肺脏轻微的可逆性改变，长期大剂量腹腔内注射对各脏器系统无明显影响。
In order to determine the safety of clinical use of bovine pulmonary surfactant (open plug lung), local irritation test, acute toxicity test and long-term toxicity test were carried out in rats and rabbits. The results showed that open plug the lungs is a safer preparation, conventional dose intratracheal instillation will not have toxic effects, multiple or large doses of intratracheal administration can lead to slight reversible lung changes, long-term high-dose intraperitoneal injection of The viscera system has no significant effect.